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首页> 外文OA文献 >HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage
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HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage

机译：复发性流产女性中的HLA-C抗体表明抗体介导的排斥是导致复发性流产的机制之一

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HLA-C is the only polymorphic classical HLA I antigen expressed on trophoblast cells. It is known that higher incidence of C4d deposition on trophoblast cells is present in women with recurrent miscarriage. C4d is a footprint of antibody-mediated classical complement activation. Therefore, this study hypothesize that antibodies against HLA-C may play a role in the occurrence of unexplained consecutive recurrent miscarriage. Present case control study compared the incidence of HLA-C specific antibodies in 95 women with at least three consecutive miscarriages and 105 women with uneventful pregnancy. In the first trimester of the next pregnancy, presence and specificity of HLA antibodies were determined and their complement fixing ability. The incidence of HLA antibodies was compared with uni- and multivariate logistic regression models adjusting for possible confounders. Although in general a higher incidence of HLA antibodies was found in women with recurrent miscarriage 31.6% vs. in control subjects 9.5% (adjusted OR 4.3, 95% CI 2.0-9.5), the contribution of antibodies against HLA-C was significantly higher in women with recurrent miscarriage (9.5%) compared to women with uneventful pregnancy (1%) (adjusted OR 11.0, 95% CI 1.3-89.0). In contrast to the control group, HLA-C antibodies in the recurrent miscarriage group were more often able to bind complement. The higher incidence of antibodies specific for HLA-C in women with recurrent miscarriage suggests that HLA-C antibodies may be involved in the aetiology of unexplained consecutive recurrent miscarriage
机译：HLA-C是在滋养层细胞上表达的唯一多态经典HLA I抗原。众所周知，反复流产的女性中，滋养层细胞上C4d沉积的发生率更高。 C4d是抗体介导的经典补体激活的足迹。因此，本研究假设针对HLA-C的抗体可能在无法解释的连续反复流产的发生中起作用。本病例对照研究比较了95例至少连续3次流产的妇女和105例妊娠顺利的妇女中HLA-C特异性抗体的发生率。在下一次怀孕的前三个月中，确定HLA抗体的存在和特异性及其补体固定能力。将HLA抗体的发生率与针对可能的混杂因素进行了调整的单变量和多变量logistic回归模型进行了比较。尽管一般而言，流产妇女中HLA抗体的发生率较高，为31.6％，而对照组为9.5％（校正OR为4.3，95％CI为2.0-9.5），但抗HLA-C抗体的贡献显着更高。反复流产的女性（9.5％）与妊娠顺利的女性（1％）（校正后的OR 11.0，95％CI 1.3-89.0）。与对照组相反，复发性流产组中的HLA-C抗体通常能够结合补体。复发性流产女性中HLA-C特异性抗体的较高发生率表明，HLA-C抗体可能参与了无法解释的连续性反复流产的病因

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